3/3/2024 0 Comments Fake 3D multimedia fusion 2![]() Several protocols take advantage of sacrificial 3D bioprinting to enhance cell density and scale, but these protocols also rely on large vessel channels to supply oxygen and nutrients, and lack a network of capillaries. Nearly all organotypic tissue engineering protocols involve the co-culture of parenchymal and endothelial cells, thereby generating vascularized material-free microtissues (high cell density) or bulk hydrogel tissues (low cell density). ![]() The promise of human organotypic tissues for tissue development, disease modelling, and drug testing is widely recognized, but limitations around cell density, vascular structure, and scale must be solved before that potential is realized. view moreĬredit: By Zhenzhen Zhou, Changru Liu, Yuting Guo, Yuan Pang and Wei Sun. Further assembly of these pre-vascularized modules, can be used for 1) tissue repair and regeneration, 2) organ-scale tissue manufacturing, and 3) advanced tissue modeling. The common approaches for module vascularization include 1) fusion of vascular modules and other modules, 2) fusion of homogeneous modules containing vascular and other cells, and 3) fusion of vascularized modules and artificial vascular tubes.
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